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KMID : 0378019950380080079
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New Medical Journal
1995 Volume.38 No. 8 p.79 ~ p.86
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Clinical Study of Clarithromycin in Outpatients with Acute Maxillary Sinusitis
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Abstract
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To evaluate the efficacy and safety of Clarithromycin(Klaricid) in the treatment of acute sinusitis, a open, non-comparative, outpatient study was performed. Thirty patient(14 males, 16 females) were randomly assigned to receive clarithromycin 500mg(two 250mg tablets) 12-hourly orally for 10 days.
Clinical signs and symptoms were assessed prior to treatment, 5 days during treatment and 2 days after treatment Sinus culture, blood and urine laboratory profile, and simple sinus radiography were assessed prior to treatment and 2 days after treatment
Clarithromycin achieved a clinical success rate of 96.7% after treatment and radio logic resolution or improvement was observed in 86.7% of patients. There was no abnormal findings in laboratory test after treatment Adverse effects were noted in 6.6% of gastrointestinal disturbances, such as indigestion and skin rash, were commonly occuring in the treatment of clarithromycin.
The results of this study suggest that clarithromycin may be effective and well tolerated in the treatment of acute maxillary sinusitis.
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